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1. Zinc Binuclear Cluster
Zinc binuclear clusters are motifs found in transcriptional regulatory proteins in fungi. An early zinc binuclear cluster was originally thought to be similar to previously described zinc fingers, with four cysteines forming a tetrahedral zinc binding site (Johnston, 1987; PMID 3299106). Subsequent structural studies demonstrated that the zinc binulear cluster consists of 6 cysteine residues that are bound to two zinc atoms (Pan, 1990; PMID 2107541, Marmorstein, PMID: 1557122). This documentary was prepared by Paul Craig while on sabbatical at University of California, San Diego.

2. Glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is the enzyme that initiates the second (payoff) stage of glycolysis. GAPDH catalyzes the reaction that converts glyceraldehyde 3-phosphate (GAP) into 1,3 bisphosphoglycerate (1,3 BPG) (and the reverse reaction in gluconeogenesis). GAPDH oxidizes and phosphorylates GAP to produce 1,3-BPG. In this reaction, phosphorylation adds an inorganic phosphate tCo the carbony carbon of GAP, which also requires the oxidation of that carbonyl group (and reduction of NAD+ to NADH). This documentary was prepared by Murtaza Mogri, while he was a student in Philip Bourne's Pharmacology 207 course (Using Internet Resources in Molecular Biology), Fall quarter, 2001-2002 academic year.

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